Bivalent peptides as PDZ domain ligands
نویسندگان
چکیده
منابع مشابه
A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands.
PDZ domain-containing proteins and their interaction partners are mutated in numerous human diseases and function in complexes regulating epithelial polarity, ion channels, cochlear hair cell development, vesicular sorting, and neuronal synaptic communication. Among several properties of a collection of documented PDZ domain-ligand interactions, we discovered embedded in a large-scale expressio...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2007
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2007.09.035